- Amalgam - The ultimate combination of fear, hatred, and loathing.
- AlterEgo - A two-headed abomination.
- Heresy - A massive insectoid enemy.
- The Keeper - A hateful and terrible beast.
- Laura (Creature) - A shade of the past reborn in terror.
- The Sadist - Chainsaw-wielding lunatic.
- Sentinel - A wolf-like, eldritch horror.
- Shigyo - An aquatic terror.
- Trauma - A tortured soul in a husk of a body.
- Quell - A creature that can camouflage at will.
- Zehn - One of two orphaned boys, raised below the cemetery.
- Neun - One of two orphaned boys, raised below the cemetery.
- Shade - A leggy creature with a light for her head. Exclusive to DLC.